Cover Image

The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers

Michael Safaee, Michael E. Ivan, Michael C. Oh, Taemin Oh, Eli T. Sayegh, Gurvinder Kaur, Matthew Z. Sun, Orin Bloch, Andrew T. Parsa
  • Michael Safaee
    Department of Neurological Surgery, University of California, San Francisco, CA, United States
  • Michael E. Ivan
    Department of Neurological Surgery, University of California, San Francisco, CA, United States
  • Michael C. Oh
    Department of Neurological Surgery, University of California, San Francisco, CA, United States
  • Taemin Oh
    Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
  • Eli T. Sayegh
    Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
  • Gurvinder Kaur
    Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
  • Matthew Z. Sun
    Department of Neurological Surgery, University of California, San Francisco, CA, United States
  • Orin Bloch
    Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
  • Andrew T. Parsa
    Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States | aparsa@nmff.org

Abstract

G-protein coupled receptors (GPCRs) are among the most diverse and ubiquitous proteins in all of biology. The epidermal growth factorseven span transmembrane (EGF-TM7) subfamily of adhesion GPCRs is a small subset whose members are mainly expressed on the surface of leukocytes. The EGF domains on the N-terminus add significant size to these receptors and they are considered to be among the largest members of the TM7 family. Although not all of their ligands or downstream targets have been identified, there is evidence implicating the EGF-TM7 family diverse processes such as cell adhesion, migration, inflammation, and autoimmune disease. Recent studies have identified expression of EGF-TM7 family members on human neoplasms including those of the thyroid, stomach, colon, and brain. Their presence on these tissues is not surprising given the ubiquity of GPCRs, but because their functional significance and pathways are not completely understood, they are of tremendous clinical and scientific interest. Current evidence suggests that expression of certain EGF-TM7 receptors is correlated with tumor grade, confers a more invasive phenotype, and increases the likelihood of metastatic disease. In this review, we will discuss the structure, function, and regulation of these receptors. We also describe the expression of these receptors in human cancers and explore their potential mechanistic significance.

Keywords

EGF-TM7, G-protein coupled receptor, EMR2, cancer.

Full Text:

PDF
HTML
Submitted: 2013-12-03 21:25:16
Published: 2014-04-01 12:20:12
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
1421

Views:
PDF
371
HTML
439

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2014 Michael Safaee, Michael E. Ivan, Michael C. Oh, Taemin Oh, Eli T. Sayegh, Gurvinder Kaur, Matthew Z. Sun, Orin Bloch, Andrew T. Parsa

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2018     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185