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Chemotherapeutic agents for the treatment of hepatocellular carcinoma: efficacy and mode of action

Saad Shaaban, Amr Negm, Elsayed E. Ibrahim, Ahmed A. Elrazak
  • Saad Shaaban
    Department of Chemistry, Mansoura University, Egypt
  • Elsayed E. Ibrahim
    Department of Zoology, Mansoura University, Egypt
  • Ahmed A. Elrazak
    Department of Botany, Mansoura University, Egypt

Abstract

Hepatocellular carcinoma (HCC) is a dreaded malignancy that every year causes half a million deaths worldwide. Being an aggressive cancer, its incidence exceeds 700,000 new cases per year worldwide with a median survival of 6-8 months. Despite advances in prognosis and early detection, effective HCC chemoprevention or treatment strategies are still lacking, therefore its dismal survival rate remains largely unchanged. This review will characterize currently available chemotherapeutic drugs used in the treatment of HCC. The respective mode(s) of action, side effects and recommendations will be also described for each drug.

Keywords

liver cancer, hepatocellular carcinoma, molecular therapies, chemoresistance.

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Submitted: 2014-02-04 19:53:28
Published: 2014-05-28 15:23:40
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Copyright (c) 2014 Saad Shaaban, Amr Negm, Elsayed E. Ibrahim, Ahmed A. Elrazak

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