Chemotherapeutic agents for the treatment of hepatocellular carcinoma: efficacy and mode of action

Main Article Content

Saad Shaaban (1), Amr Negm (2*), Elsayed E. Ibrahim (3), Ahmed A. Elrazak (4)

1 Department of Chemistry, Mansoura University, Egypt.
2 Department of Biochemistry, Mansoura University, Egypt.
3 Department of Zoology, Mansoura University, Egypt.
4 Department of Botany, Mansoura University, Egypt.
(*) Corresponding Author:
Amr Negm
amrnigm@mans.edu.eg

Abstract

Hepatocellular carcinoma (HCC) is a dreaded malignancy that every year causes half a million deaths worldwide. Being an aggressive cancer, its incidence exceeds 700,000 new cases per year worldwide with a median survival of 6-8 months. Despite advances in prognosis and early detection, effective HCC chemoprevention or treatment strategies are still lacking, therefore its dismal survival rate remains largely unchanged. This review will characterize currently available chemotherapeutic drugs used in the treatment of HCC. The respective mode(s) of action, side effects and recommendations will be also described for each drug.

Downloads month by month

Downloads

Download data is not yet available.

Article Details

How to Cite
Shaaban, S., Negm, A., Ibrahim, E., & Elrazak, A. (2014). Chemotherapeutic agents for the treatment of hepatocellular carcinoma: efficacy and mode of action. Oncology Reviews, 8(1). https://doi.org/10.4081/oncol.2014.246