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An updated review of cribriform carcinomas with emphasis on histopathological diagnosis and prognostic significance

Giovanni Branca, Antonio Ieni, Valeria Barresi, Giovanni Tuccari, Rosario Alberto Caruso
  • Giovanni Branca
    Department of Human Pathology G. Barresi, University of Messina, Italy | giobranca81@gmail.com
  • Antonio Ieni
    Department of Human Pathology G. Barresi, University of Messina, Italy
  • Valeria Barresi
    Department of Human Pathology G. Barresi, University of Messina, Italy
  • Giovanni Tuccari
    Department of Human Pathology G. Barresi, University of Messina, Italy
  • Rosario Alberto Caruso
    Department of Human Pathology G. Barresi, University of Messina, Italy

Abstract

Cribriform is a histopathological term used to describe a neoplastic epithelial proliferation in the form of large nests perforated by many quite rounded different-sized spaces. This growth pattern may be seen in carcinomas arising in different organs, and shows important prognostic implications. Therefore, recent data in literature suggest that cribriform carcinoma is a histologically and clinically distinctive type of tumour that should be separated from other similar tumour types. In this article, the pathology of cribriform adenocarcinoma of the prostate, lung, breast, stomach, colon, thyroid, and skin is discussed with particular reference to morphologic and immunohistochemical features, differential diagnosis, and clinical behaviour.

Keywords

Cribriform carcinoma; histopathology; immunohistochemistry; differential diagnosis; prognosis.

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Submitted: 2016-09-19 21:40:34
Published: 2017-03-10 12:28:14
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Copyright (c) 2017 Giovanni Branca, Antonio Ieni, Valeria Barresi, Giovanni Tuccari, Rosario Alberto Caruso

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