Cover Image

Management of radiation therapy-induced mucositis in head and neck cancer patients. Part I: Clinical significance, pathophysiology and prevention

Wei Cheong Ngeow, Wen Lin Chai, Rosnah Binti Zain
  • Wei Cheong Ngeow
    Department of Oral & Maxillofacial Surgery Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia | ngeowy@um.edu.my
  • Wen Lin Chai
    Department of General Dental Practice and Oral & Maxillofacial Imaging, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
  • Rosnah Binti Zain
    Department of Oral Pathology, Oral Medicine and Periodontology Faculty of Dentistry,University of Malaya, Kuala Lumpur,

Abstract

Oropharyngeal mucositis is the acute inflammatory and ulcerative reaction of the oral mucosa following radiation therapy to the head and neck region. It is such a common problem that nearly all head and neck cancer patients develop some degree of mucositis. This complication is usually transient in nature but it also represents an important clinical problem as it is a painful, debilitating, dose-dependent side effect for which there is no widely acceptable prophylaxis or effective treatment. As several authoritative groups have recently either undertaken systematic reviews or issued guidelines on the management of mucositis, it is the aim of this review to provide instead an overview of all the possible remedies available, as well as highlighting to researchers the gaps that need to be filled. The first part of this review outlines the clinical significance and pathophysiology of radiation-induced mucositis, and looks into some of the preventive approaches available.

Keywords

Head and neck cancer - Radiation therapy - Mucositis - Management

Full Text:

FULL TEXT
Submitted: 2011-12-14 23:06:57
Published: 2011-12-14 00:00:00
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
574

Views:
FULL TEXT
150

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2011 Wei Cheong Ngeow, Wen Lin Chai, Rosnah Binti Zain

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2018     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185