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MicroRNAs in the diagnosis, prognosis and treatment of cancer

Violaine Havelange, Catherine E.A. Heaphy, Ramiro Garzon
  • Violaine Havelange
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH; Hematological section of the Human Genetic Center, Université Catholique de Louvain, Brussels, United States | ramiro.garzon@osumc.edu
  • Catherine E.A. Heaphy
    Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, United States
  • Ramiro Garzon
    Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, United States

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that regulate critical cell processes such as cell proliferation, apoptosis and differentiation by modulating gene expression. MiRNAs deregulation has been observed extensively in cancer. Elegant studies have demonstrated that miRNAs are involved in the initiation and progression of several malignancies. In this review we will address the role of miRNAs in the diagnosis and prognosis of cancer. The development of new drugs mimicking or blocking miRNAs will be discussed.

Keywords

MicroRNAs - Cancer - MiRNAs profiling - Diagnosis - Prognosis - Treatment

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Submitted: 2011-12-18 10:43:29
Published: 2011-12-18 00:00:00
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Copyright (c) 2011 Violaine Havelange, Catherine E.A. Heaphy, Ramiro Garzon

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