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Clinical and pathological implications of GSTM1 and GSTT1 gene deletions in sporadic breast cancer

Cassio Cardoso Filho, Gustavo Lourenço, Julia Yoriko Shinzato, Luiz Carlos Zeferino, Fernando Ferreira Costa, Carmen Silvia Passos Lima, Maria Salete Costa Gurgel
  • Cassio Cardoso Filho
    Department of Obstetrics and Gynecology, School of Medicine, Universidade Estadual de Campinas UNICAMP, Brazil | salete@caism.unicamp.br
  • Gustavo Lourenço
    Laboratory of Conventional and Molecular Cytogenetics Blood Center/UNICAMP, Brazil
  • Julia Yoriko Shinzato
    Department of Obstetrics and Gynecology, School of Medicine, Universidade Estadual de Campinas UNICAMP, Brazil
  • Luiz Carlos Zeferino
    Department of Obstetrics and Gynecology, School of Medicine, Universidade Estadual de Campinas UNICAMP, Brazil
  • Fernando Ferreira Costa
    Department of Clinical Medicine FCM/UNICAMP, Brazil
  • Carmen Silvia Passos Lima
    Department of Clinical Medicine FCM/UNICAMP, Brazil
  • Maria Salete Costa Gurgel
    Cidade Universitária Zeferino Vaz Barão Geraldo, Campinas, Brazil

Abstract

There is a lack of consensus about the influence of GST M1/T1 gene deletions (DEL) on sporadic breast cancer (SBC). To evaluate the occurrence of DEL in 177 SBC cases and in 169 controls, and compare clinical and biological characteristics. A lower frequency of GSTM1 DEL was observed in mulatto women, OR=0.48 (0.24–0.98). The risk of nuclear grade 3 tumors (GN3) was lower in patients with GSTT1 DEL, OR=0.37 (0.15–0.90). DEL of at least one gene (ALOG) was associated with women who had not breastfed, OR=0.41 (0.19–0.88), and with negative hormone receptor, HR–, ORadj=2.25 (1.03–4.90). Both genes deleted (BGD) was associated with non-classic invasive ductal carcinoma (NCDC), ORadj=12.09 (1.03–142.03). Mulatto women with SBC had a lower frequency of GSTM1 DEL, while tumors differentiated were related to GSTT1 DEL. HRtumors were related with DEL ALOG, and the BGD was associated with a greater risk of NCDC.

Keywords

Breast cancer - Genetic polymorphisms - Glutathione S-transferase - GSTM1 - GSTT1

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Submitted: 2011-12-14 15:50:17
Published: 2011-12-14 00:00:00
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Copyright (c) 2011 Cassio Cardoso Filho, Gustavo Lourenço, Julia Yoriko Shinzato, Luiz Carlos Zeferino, Fernando Ferreira Costa, Carmen Silvia Passos Lima, Maria Salete Costa Gurgel

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