Clinical and pathological implications of GSTM1 and GSTT1 gene deletions in sporadic breast cancer

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Cassio Cardoso Filho (1*), Gustavo Lourenço (2), Julia Yoriko Shinzato (3), Luiz Carlos Zeferino (4), Fernando Ferreira Costa (5), Carmen Silvia Passos Lima (6), Maria Salete Costa Gurgel (7)

1 Department of Obstetrics and Gynecology, School of Medicine, Universidade Estadual de Campinas UNICAMP, Brazil.
2 Laboratory of Conventional and Molecular Cytogenetics Blood Center/UNICAMP, Brazil.
3 Department of Obstetrics and Gynecology, School of Medicine, Universidade Estadual de Campinas UNICAMP, Brazil.
4 Department of Obstetrics and Gynecology, School of Medicine, Universidade Estadual de Campinas UNICAMP, Brazil.
5 Department of Clinical Medicine FCM/UNICAMP, Brazil.
6 Department of Clinical Medicine FCM/UNICAMP, Brazil.
7 Cidade Universitária Zeferino Vaz Barão Geraldo, Campinas, Brazil.
(*) Corresponding Author:
Cassio Cardoso Filho
salete@caism.unicamp.br

Abstract

There is a lack of consensus about the influence of GST M1/T1 gene deletions (DEL) on sporadic breast cancer (SBC). To evaluate the occurrence of DEL in 177 SBC cases and in 169 controls, and compare clinical and biological characteristics. A lower frequency of GSTM1 DEL was observed in mulatto women, OR=0.48 (0.24–0.98). The risk of nuclear grade 3 tumors (GN3) was lower in patients with GSTT1 DEL, OR=0.37 (0.15–0.90). DEL of at least one gene (ALOG) was associated with women who had not breastfed, OR=0.41 (0.19–0.88), and with negative hormone receptor, HR–, ORadj=2.25 (1.03–4.90). Both genes deleted (BGD) was associated with non-classic invasive ductal carcinoma (NCDC), ORadj=12.09 (1.03–142.03). Mulatto women with SBC had a lower frequency of GSTM1 DEL, while tumors differentiated were related to GSTT1 DEL. HRtumors were related with DEL ALOG, and the BGD was associated with a greater risk of NCDC.

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How to Cite
Cardoso Filho, C., Lourenço, G., Shinzato, J. Y., Zeferino, L. C., Ferreira Costa, F., Passos Lima, C. S., & Costa Gurgel, M. S. (2011). Clinical and pathological implications of GSTM1 and GSTT1 gene deletions in sporadic breast cancer. Oncology Reviews, 2(1), 36-43. Retrieved from http://www.oncologyreviews.org/index.php/or/article/view/oncol.2008.36