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The role of molecular strategies in the evaluation of surgical margins in oropharyngeal squamous cell carcinoma

Anastasios N. Kanatas, Andrew T. Harris, Michael Messenger, David Houghton, Simon N. Rogers
  • Anastasios N. Kanatas
    Oral and Maxillofacial Department, Leeds Dental Institute, The Worsley Building, Leeds, United Kingdom | a.kanatas@doctors.org.uk
  • Andrew T. Harris
    Oral Biology, University of Leeds, Leeds,
  • Michael Messenger
    Tissue Engineering Research, Department of Oral Biology, Leeds Dental Institute, Leeds, United Kingdom
  • David Houghton
    Oral and Facial Specialties Department, Pinderfields General Hospital, Wakefield, United Kingdom
  • Simon N. Rogers
    Regional Maxillofacial Unit, Faculty of Health, Edge Hill University, University Hospital Aintree, Liverpool,

Abstract

The recurrence of a tumour at the resection margins in head and neck squamous cell carcinoma (HNSCC) has profound implications on the morbidity and mortality of the patient. At present HNSCC does not undergo any form of molecular analysis to aid treatment strategy and prognosticate for those individuals at higher risk of recurrence. This article aims to review current research into molecular strategies for tumour evaluation, highlighting conflicting evidence and possible novel concepts for further exploration.

Keywords

Head and neck cancer - Epigenetics - Spectroscopy - Surgical margins - Oral and maxillofacial cancer

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Submitted: 2011-12-14 10:58:09
Published: 2011-12-14 00:00:00
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Copyright (c) 2011 Anastasios N. Kanatas, Andrew T. Harris, Michael Messenger, David Houghton, Simon N. Rogers

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