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The role of vitamin D in breast cancer

Tu Tu Aung, Sreenivasa R. Chandana, Karl J. D’Silva, Nikolay V. Dimitrov
  • Tu Tu Aung
    Division of Hematology/Oncology, Department of Medicine, Michigan State University, East Lansing, United States | dohmta@msu.edu
  • Sreenivasa R. Chandana
    Division of Hematology/Oncology, Department of Medicine, Michigan State University, East Lansing, United States
  • Karl J. D’Silva
    Division of Hematology/Oncology, Department of Medicine, Michigan State University, East Lansing, United States
  • Nikolay V. Dimitrov
    Division of Hematology/Oncology, Department of Medicine, Michigan State University, East Lansing, United States

Abstract

The biological role of vitamin D outside of calcium homeostasis is still under evaluation. The ability of vitamin D to inhibit cell proliferation and induce differentiation makes it a potential modifier of neoplastic transformation. Vitamin D affects the cell cycle, apoptosis, hormone receptors, angiogenesis, and hypoxia, all of which are related to the breast cancer growth, progression and metastasis. A large percentage of the industrial-world population is deficient in vitamin D. Epidemiological evidence suggests that vitamin D deficiency increases the risk of breast cancer. Vitamin D may have synergistic, additive, or antagonistic effects when combined with other therapeutic agents against breast cancer. Vitamin D appears to depress aromatase inhibitor by acting through cytochrome P 450. This evidence along with pre-clinical and clinical studies, justify the inclusion of vitamin D in future clinical trials related to breast cancer in order to determine its efficacy as a part of the breast cancer therapeutic armament.

Keywords

Vitamin D - Breast cancer - Carcinogenesis - Prevention - Treatment

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Submitted: 2011-12-13 09:45:37
Published: 2011-12-14 00:00:00
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Copyright (c) 2011 Tu Tu Aung, Sreenivasa R. Chandana, Karl J. D’Silva, Nikolay V. Dimitrov

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