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Neuroendocrine tumours (NETs) represent a group of neoplasias characterized by significant histopathological and biological heterogeneity. Diagnosis of neuroendocrine tumours relies upon histological examination augmented by newer techniques, such as pet-dotatoc scan. Surgery represents the only curative therapeutic approach. In advanced unresectable disease, medical treatment is the best choice. Somatostatin analogues allow adequate control of the carcinoid syndrome with a low effect on tumour cell growth. Chemotherapy has a good activity only in poor prognosis patients. According to the clinical course of the disease, a multimodal approach could be evaluated in selected cases. New target therapy including multikinase inhibitors, monoclonal antibody and m-tor inhibitors is now under clinical investigation for the treatment of advanced NETs. Preliminary results demonstrated a good activity in terms of disease control rate and tumour shrinkage.
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How to Cite
Bajetta, E., Procopio, G., Pusceddu, S., Pietrantonio, F., Milione, M., Maccauro, M., Verzoni, E., Guadalupi, V., & Platania, M. (2011). From biology to clinical experience: evolution in the knowledge of neuroendocrine tumours. Oncology Reviews, 3(2), 79-87. https://doi.org/10.4081/oncol.2009.79
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