Vγ9Vδ2 T cells as a promising innovative tool for immunotherapy of hematologic malignancies

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Serena Meraviglia (1*), Carmela La Mendola (2), Valentina Orlando (3), Francesco Scarpa (4), Giuseppe Cicero (5), Francesco Dieli (6)

1 Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Universita` di Palermo, Palermo, Italy.
2 Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Universita` di Palermo, Palermo, Italy.
3 Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Universita` di Palermo, Palermo, .
4 Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Universita` di Palermo, Palermo, Italy.
5 Dipartimento di Discipline Chirurgiche ed Oncologiche, Universita` di Palermo, Palermo, Italy.
6 Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Universita` di Palermo, Palermo, Italy.
(*) Corresponding Author:
Serena Meraviglia
dieli@unipa.it

Abstract

The potent anti-tumor activities of γδ T cells, their ability to produce pro-inflammatory cytokines, and their strong cytolytic activity have prompted the development of protocols in which γδ agonists or ex vivo-expanded γδ cells are administered to tumor patients. γδ T cells can be selectively activated by either synthetic phosphoantigens or by drugs that enhance their accumulation into stressed cells as aminobisphosphonates, thus offering new avenues for the development of γδ T cell-based immunotherapies. The recent development of small drugs selectively activating Vγ9Vδ2 T lymphocytes, which upregulate the endogenous phosphoantigens, has enabled the investigators to design the experimental approaches of cancer immunotherapies; several ongoing phase I and II clinical trials are focused on the role of the direct bioactivity of drugs and of adoptive cell therapies involving phosphoantigen- or aminobisphosphonate-activated Vγ9Vδ2 T lymphocytes in humans. In this review, we focus on the recent advances in the activation/expansion of γδ T cells in vitro and in vivo that may represent a promising target for the design of novel and highly innovative immunotherapy in patients with hematologic malignancies.

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How to Cite
Meraviglia, S., La Mendola, C., Orlando, V., Scarpa, F., Cicero, G., & Dieli, F. (2011). Vγ9Vδ2 T cells as a promising innovative tool for immunotherapy of hematologic malignancies. Oncology Reviews, 4(4), 211-218. https://doi.org/10.4081/oncol.2010.211