Cover Image

Neoadjuvant endocrine treatment of women with breast cancer

Julian Iturbe, Ariel Zwenger, Carlos Vallejo, Bernardo Leone, Pablo Leone
  • Julian Iturbe
    Grupo Oncologico Cooperativo del Sur (GOCS), Neuquen, Argentina | info@gocsbhb.com.ar
  • Ariel Zwenger
    Grupo Oncologico Cooperativo del Sur (GOCS), Neuquen, Argentina
  • Carlos Vallejo
    Grupo Oncologico Cooperativo del Sur (GOCS), Neuquen, Argentina
  • Bernardo Leone
    Grupo Oncologico Cooperativo del Sur (GOCS), Neuquen, Argentina
  • Pablo Leone
    Department of Internal Medicine, University of Miami, Jackson Memorial Hospital,, United States

Abstract

Neoadjuvant therapy has four goals in breast cancer: decrease tumor volume to operate tumors that initially were inoperable, increase the number of conservative surgeries, evaluate the chemosensitivity in vivo and analyze the management of micrometastases. Neoadjuvant treatment provides a unique setting in which we can monitor clinical, pathological, proliferative and molecular responses. Combining different strategies such us surgery, radiation therapy, chemotherapy, and endocrine therapy has contributed substantially to the survival improvement in breast cancer. Thirdgeneration aromatase inhibitors have proven to be superior to tamoxifen in the adjuvant and, more recently, the neoadjuvant treatment of postmenopausal patients. The need to define how to select the patients that will benefit the most from these therapies, the optimal duration of treatment, the bestmethod to evaluate the treatment response, the identification of predictive factors for response, and the superiority of certain endocrine agents over others have been reviewed. We have carried out a critical analysis of the current literature on the utilization of endocrine therapy in the neoadjuvant setting for breast cancer. This review discusses the current evidence regarding primary endocrine therapy and the current opinions on length of treatment and measurement of response prior to surgery.

Keywords

Breast cancer - Neoadjuvant therapy - Hormone therapy Tamoxifen - Aromatase inhibitors

Full Text:

FULL TEXT
Submitted: 2011-12-01 16:24:31
Published: 2011-09-30 00:00:00
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
734

Views:
FULL TEXT
212

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2011 Julian Iturbe, Ariel Zwenger, Carlos Vallejo, Bernardo Leone, Pablo Leone

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2018     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185