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Molecular pharmacokinetic determinants of anticancer kinase inhibitors in humans

Julie Scholler, Dominique Leveque
  • Dominique Leveque
    Affiliation not present

Abstract

This review presents the published data regarding the molecular determinants (drug metabolizing enzymes, drug transporters and orphan nuclear receptors) of approved anticancer kinase inhibitors pharmacokinetics in humans. The clinical impact of these determinants (drug disposition and drug–drug interactions) is also discussed.

Keywords

Kinase inhibitor - Cancer - Imatinib - Dasatinib - Nilotinib - Erlotinib - Gefitinib - Sunitinib - Sorafenib - Lapatinib - Pazopanib - Pharmacokinetics - Enzymes - Drug transporters

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Submitted: 2011-11-30 10:53:30
Published: 2011-06-30 00:00:00
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Copyright (c) 2011 Julie Scholler, Dominique Leveque

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