Cover Image

A role of active brown adipose tissue in cancer cachexia?

Emiel Beijer, Janna Schoenmakers, Guy Vijgen, Fons Kessels, Anne-Marie Dingemans, Patrick Schrauwen, Miel Wouters, Wouter van Marken Lichtenbelt, Jaap Teule, Boudewijn Brans
  • Emiel Beijer
    Department of Nuclear Medicine, University Medical Center, Maastricht, Netherlands
  • Janna Schoenmakers
    Department of Respiratory Medicine, University Medical Center, Maastricht, Netherlands
  • Guy Vijgen
    Departments of Surgery; Human Biology; NUTRIM School for Nutrition, Toxicology and Metabolism, University Medical Center, Maastricht, Netherlands
  • Fons Kessels
    Department of Clinical Epidemiology and Medical Technology Assessment (MTA); CAPHRI School for Public Health and Primary Careh, University Medical Center, Maastricht, Netherlands
  • Anne-Marie Dingemans
    Department of Respiratory Medicine; GROW School for Oncology and Developmental Biology, University Medical Center, Maastricht, Netherlands
  • Patrick Schrauwen
    Department of Human Biology; NUTRIM School for Nutrition, Toxicology and Metabolism, University Medical Center, Maastricht, Netherlands
  • Miel Wouters
    Department of Respiratory Medicine; NUTRIM School for Nutrition, Toxicology and Metabolism, University Medical Center, Maastricht, Netherlands
  • Wouter van Marken Lichtenbelt
    Department of Human Biology; NUTRIM School for Nutrition, Toxicology and Metabolism, University Medical Center, Maastricht, Netherlands
  • Jaap Teule
    Department of Nuclear Medicine, University Medical Center, Maastricht, Netherlands
  • Boudewijn Brans
    Department of Nuclear Medicine; GROW School for Oncology and Developmental Biology, University Medical Center, Maastricht, Netherlands | b.brans@mumc.nl

Abstract

Until a few years ago, adult humans were not thought to have brown adipose tissue (BAT). Now, this is a rapidly evolving field of research with perspectives in metabolic syndromes such as obesity and new therapies targeting its bio-energetic pathways. White, brown and socalled brite adipose fat seem to be able to trans-differentiate into each other, emphasizing the dynamic nature of fat tissue for metabolism. Human and animal data in cancer cachexia to date provide some evidence for BAT activation, but its quantitative impact on energy expenditure and weight loss is controversial. Prospective clinical studies can address the potential role of BAT in cancer cachexia using 18F-fluorodeoxyglucose positron emission tomography-computed tomography scanning, with careful consideration of co-factors such as diet, exposure to the cold, physical activity and body mass index, that all seem to act on BAT recruitment and activity.

Keywords

cancer, cachexia, brown adipose tissue, brown fat, energy expenditure, thermogenesis, UCP-1, 18F-FDG PET-CT.

Full Text:

PDF
Supplementary
HTML
Submitted: 2012-02-03 13:46:58
Published: 2012-06-12 11:59:02
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
3026

Views:
PDF
516
Supplementary
76
HTML
748

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2012 Emiel Beijer, Janna Schoenmakers, Guy Vijgen, Fons Kessels, Anne-Marie Dingemans, Patrick Schrauwen, Miel Wouters, Wouter van Marken Lichtenbelt, Jaap Teule, Boudewijn Brans

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2018     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185