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Role of viruses in oral squamous cell carcinoma

Rashmi Metgud, Madhusudan Astekar, Meenal Verma, Ashish Sharma
  • Rashmi Metgud
    Department of Oral and Maxillofacial Pathology, Pacific Dental College and Hospital, Debari, Udaipur (Rajasthan), India
  • Madhusudan Astekar
    Department of Oral and Maxillofacial Pathology, Pacific Dental College and Hospital, Debari, Udaipur (Rajasthan), India | madhu.tanu@gmail.com
  • Meenal Verma
    Department of Oral and Maxillofacial Pathology, Pacific Dental College and Hospital, Debari, Udaipur (Rajasthan), India
  • Ashish Sharma
    Department of Oral and Maxillofacial Pathology, Pacific Dental College and Hospital, Debari, Udaipur (Rajasthan), India

Abstract

The etiology of oral squamous cell carcinoma (OSCC) is complex and involves many factors. The most clearly defined risk factors are smoking and alcohol, which substantially increase the risk of oral SCC. However, despite this clear association, a substantial proportion of patients develop OSCC without exposure to them, emphasizing the role of other risk factors such as genetic susceptibility and oncogenic viruses. Some viruses are strongly associated with OSCC while the association of others is less frequent and may depend on co-factors for their carcinogenic effects. Therefore, the exact role of viruses must be evaluated with care in order to improve the diagnosis and treatment of OSCC.

Keywords

cellular proteins, viral genome, transforming region, apoptosis, caspases, transforming genes, oncogene proteins, squamous cell carcinoma, AIDS, HPV, EBV, vaccines.

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Submitted: 2012-04-28 15:00:53
Published: 2012-09-14 18:13:13
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Copyright (c) 2012 Rashmi Metgud, Madhusudan Astekar, Meenal Verma, Ashish Sharma

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