Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases

DOI https://doi.org/10.4081/oncol.2012.e6

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Published Jun 14, 2012
Reviews

Issue
Vol 6 No 1 (2012)
Pages
e6
Keywords
liver metastasis, colorectal cancer, chemotherapy, neo-adjuvant chemotherapy, biological therapy, bevacizumab, cetuximab.
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Luigi Rossi (1), Angelo Zullo (2), Federica Zoratto (3), Anselmo Papa (4), Martina Strudel (5), Maria Colonna (6), Silverio Tomao (7*)

1 Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina – “Sapienza” University of Rome, Italy.
2 Gastroenterology and Digestive Endoscopy; Nuovo Regina Margherita Hospital, Rome, Italy.
3 Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina – “Sapienza” University of Rome, Italy.
4 Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina – “Sapienza” University of Rome, Italy.
5 Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina – “Sapienza” University of Rome, Italy.
6 , Italy.
7 Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina – “Sapienza” University of Rome, Italy.
(*) Corresponding Author:
Silverio Tomao
silverio.tomao@uniroma1.it

Abstract

Although surgery is the most effective treatment for liver metastases in colorectal cancer patients, only 15-20% of these patients are suitable for a radical surgical approach, and metastases recurrence may occur at follow up. In the last decade, the use of pre-operative chemotherapy in combination with new biological drugs has been introduced. We reviewed data of neo-adjuvant chemotherapy strategies aimed at increasing the resection rate of liver metastases in colorectal cancer patients who were initially considered unresectable.

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How to Cite
Rossi, L., Zullo, A., Zoratto, F., Papa, A., Strudel, M., Colonna, M., & Tomao, S. (2012). Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases. Oncology Reviews, 6(1), e6. https://doi.org/10.4081/oncol.2012.e6
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