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Therapeutic strategies for synchronous and multiple liver metastases from colorectal cancer

Shinji Osada, Hisashi Imai, Yoshiyuki Sasaki, Yoshihiro Tanaka, Nobuhisa Matsuhashi, Naoki Okumura, Michitaka Nagase, Kenichi Nonaka, Kazuhiro Yoshida
  • Shinji Osada
    Surgical Oncology, Gifu University School of Medicine, Gifu, Japan | sting@gifu-u.ac.jp
  • Hisashi Imai
    Surgical Oncology, Gifu University School of Medicine, Gifu, Japan
  • Yoshiyuki Sasaki
    Surgical Oncology, Gifu University School of Medicine, Gifu, Japan
  • Yoshihiro Tanaka
    Surgical Oncology, Gifu University School of Medicine, Gifu, Japan
  • Nobuhisa Matsuhashi
    Surgical Oncology, Gifu University School of Medicine, Gifu, Japan
  • Naoki Okumura
    Surgical Oncology, Gifu University School of Medicine, Gifu, Japan
  • Michitaka Nagase
    Surgical Oncology, Gifu University School of Medicine, Gifu, Japan
  • Kenichi Nonaka
    Surgical Oncology, Gifu University School of Medicine, Gifu, Japan
  • Kazuhiro Yoshida
    Surgical Oncology, Gifu University School of Medicine, Gifu, Japan

Abstract

Metastasis in the liver is one of the most critical factors in the prognosis of patients with colorectal cancer. The incidence of synchronous liver metastasis has been found to be approximately 20-25%, but the optimal timing of surgical resection remains controversial. Neoadjuvant chemotherapy has also been found to be beneficial not only for initially unresectable but also resectable synchronous metastases and traditional surgical strategies of hepatic resection with past chemotherapeutic regimens have been used less and less over the past several years. This review will discuss treatments in association with the recently developed chemotherapeutic regimens.

Keywords

Therapeutic strategies for synchronous and multiple liver metastases from colorectal cancer

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Submitted: 2012-03-21 02:21:52
Published: 2012-06-14 18:53:00
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Copyright (c) 2012 Shinji Osada, Hisashi Imai, Yoshiyuki Sasaki, Yoshihiro Tanaka, Nobuhisa Matsuhashi, Naoki Okumura, Michitaka Nagase, Kenichi Nonaka, Kazuhiro Yoshida

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