Bone marrow blood vessels: normal and neoplastic niche

  • Saeid Shahrabi | najmaldinsaki@gmail.com Department of Biochemistry and Hematology, Semnan University of Medical Sciences, Semnan, Iran, Islamic Republic of.
  • Hadi Rezaeeyan Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Islamic Republic of.
  • Ahmad Ahmadzadeh Health Research Institute, Research Center of Thalassemia & Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Islamic Republic of.
  • Mohammad Shahjahani Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Islamic Republic of.
  • Najmaldin Saki Health Research Institute, Research Center of Thalassemia & Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Islamic Republic of.

Abstract

Blood vessels are among the most important factors in the transport of materials such as nutrients and oxygen. This study will review the role of blood vessels in normal bone marrow hematopoiesis as well as pathological conditions like leukemia and metastasis. Relevant literature was identified by a Pubmed search (1992-2016) of English-language papers using the terms bone marrow, leukemia, metastasis, and vessel. Given that blood vessels are conduits for the transfer of nutrients, they create a favorable situation for cancer cells and cause their growth and development. On the other hand, blood vessels protect leukemia cells against chemotherapy drugs. Finally, it may be concluded that the vessels are an important factor in the development of malignant diseases.

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Published
2016-11-24
Section
Reviews
Keywords:
Bone marrow, niche, vessel.
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How to Cite
Shahrabi, S., Rezaeeyan, H., Ahmadzadeh, A., Shahjahani, M., & Saki, N. (2016). Bone marrow blood vessels: normal and neoplastic niche. Oncology Reviews, 10(2). https://doi.org/10.4081/oncol.2016.306

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