Chemotherapy resistance mechanisms in advanced skin cancer

  • Bhuvanesh Sukhlal Kalal | bhuvanesh611@gmail.com Department of Biochemistry, Yenepoya Medical College; Yenepoya Research Centre, Yenepoya University, Mangaluru, India. http://orcid.org/0000-0002-2560-3778
  • Dinesh Upadhya Yenepoya Research Centre, Yenepoya University, Mangaluru, India.
  • Vinitha Ramanath Pai Department of Biochemistry, Yenepoya Medical College, Yenepoya University, Mangaluru, India.

Abstract

Melanoma is a most dangerous and deadly type of skin cancer, and considered intrinsically resistant to both radiotherapy and chemotherapy. It has become a major public health concern as the incidence of melanoma has been rising steadily over recent decades with a 5-year survival remaining less than 5%. Detection of the disease in early stage may be curable, but late stage metastatic disease that has spread to other organs has an extremely poor prognosis with a median survival of less than 10 months. Since metastatic melanoma is unresponsive to therapy that is currently available, research is now focused on different treatment strategies such as combinations of surgery, chemotherapy and radiotherapy. The molecular basis of resistance to chemotherapy seen in melanoma is multifactorial; defective drug transport system, altered apoptotic pathway, deregulation of apoptosis and/or changes in enzymatic systems that mediate cellular metabolic machinery. Understanding of alterations in molecular processes involved in drug resistance may help in developing new therapeutic approaches to treatment of malignant melanoma.

Downloads

Download data is not yet available.
Published
2017-03-24
Section
Reviews
Keywords:
Drug-resistance, melanoma, chemotherapy, BRAF mutation, combination therapy, review.
Statistics
Abstract views: 2007

PDF: 1156
HTML: 560
Share it

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

How to Cite
Kalal, B., Upadhya, D., & Pai, V. (2017). Chemotherapy resistance mechanisms in advanced skin cancer. Oncology Reviews, 11(1). https://doi.org/10.4081/oncol.2017.326