Carcinogenesis-relevant biological events in the pathophysiology of the efferocytosis phenomenon

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Gargi Sachin Sarode
Sachin C. Sarode *
Nikunj Maniyar
Nilesh Kumar Sharma
Shankargouda Patil
(*) Corresponding Author:
Sachin C. Sarode | drsachinsarode@gmail.com

Abstract

The effective removal of cells undergoing programmed cell death, which is referred to as efferocytosis, prevents the leakage of intracellular contents into the surrounding tissue, which could lead to tissue damage and inflammation. Efferocytosis involves a coordinated orchestration of multiple steps that lead to a swift, coherent and immunologically silent removal of dying cells. The release of wound healing cytokines, which resolve inflammation and enhance tissue repair, is an important feature of efferocytosis. However, in addition to the healing cytokines released during efferocytosis, the immunosuppressive action of cytokines promotes the tumor microenvironment, enhances the motility of cancer cells and promotes the evasion of antitumor immunity. The aim of the present review was to comprehensively discuss the efferocytosis phenomenon, the important players associated with this process and their role in cancer-related biological events.


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Author Biographies

Gargi Sachin Sarode, Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune, Maharashtra

Department of Oral Pathology and Microbiology

Professor

Sachin C. Sarode, Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune, Maharashtra

Department of Oral Pathology and Microbiology

Professor

Nikunj Maniyar, Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune, Maharashtra

Dr. D.Y. Patil Dental College and Hospital, Pune.

Final Year BDS student

Nilesh Kumar Sharma, Cancer and Translational Research Lab, Dr. D.Y. Patil Biotechnology & Bioinformatics Institute, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra

Cancer and Translational Research Lab

Associate Professor

Shankargouda Patil, Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan

Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology

Associate Professor

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