Cancer-related cognitive impairment in breast cancer survivors: An examination of conceptual and statistical cognitive domains using principal component analysis

  • Maude Lambert School of Psychology, University of Ottawa, Ottawa, Ontario, Canada.
  • Lea Ann Ouimet School of Psychology, University of Ottawa, Ottawa, Ontario, Canada.
  • Cynthia Wan School of Psychology, University of Ottawa, Ottawa, Ontario, Canada.
  • Angela Stewart School of Psychology, University of Ottawa, Ottawa, Ontario, Canada.
  • Barbara Collins Ottawa Hospital, Civic Campus, Ottawa, Ontario, Canada.
  • Irene Vitoroulis School of Psychology, University of Ottawa, Ottawa, Ontario, Canada.
  • Catherine Bielajew | catch@uottawa.ca School of Psychology, University of Ottawa, Ottawa, Ontario, Canada.

Abstract

There is a great deal of variability in the composition of neuropsychological test batteries used in the assessment of cancerrelated cognitive impairment (CRCI). Not only the development of a gold standard approach for CRCI assessment would allow for easier identification of women suffering from CRCI but it would also promote optimal care for survivors. As a first step towards the development of a valid and reliable unified test battery, the objective of this study was to verify whether the theoretical domains commonly used in CRCI assessment are statistically supported, before and after breast cancer treatment. Principal component analyses (PCA) were performed on the results from 23 neuropsychological tests grouped into eight conceptual domains. For baseline data, the Kaiser-Meyer-Olkin was .82 and Bartlett’s χ2(253, N=95) = 949.48, P<0.001. A five-component solution explained 60.94% of the common variance. For the post-treatment data, the Kaiser-Meyer-Olkin was .83 and Bartlett’s χ2(253, N=95) = 1007.21, P<0.001 and a five component solution explained 62.03% of the common variance. Although a visual comparison of the theoretical model with those determined via PCA indicated important overlap between conceptual domains and statistical components, significant dissimilarities were also observed.

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Published
2018-08-28
Section
Reviews
Keywords:
Breast cancer survivors, cancer-related cognitive impairment, battery tests, principal component analyses.
Statistics
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How to Cite
Lambert, M., Ouimet, L. A., Wan, C., Stewart, A., Collins, B., Vitoroulis, I., & Bielajew, C. (2018). Cancer-related cognitive impairment in breast cancer survivors: An examination of conceptual and statistical cognitive domains using principal component analysis. Oncology Reviews, 12(2). https://doi.org/10.4081/oncol.2018.371