Physiopathology and diagnosis of cardiotoxicity in patients submitted to chemotherapy treatment

  • Filipe C. Marmelo | Department of Physiology and Cardiothoracic Surgery, Porto University Medical School; Lisbon University Medical School, Portugal.
  • Cátia F.R. Sá Polytechnic Institute of Castelo Branco, Dr Lopes Dias School of Health; Service of Cardiothoracic Surgery, Coimbra Hospital Center, Portugal.


Cardiovascular diseases and neoplastic diseases are the two main causes of morbidity and mortality in the world. Treated cancer patients usually develop cardiac diseases late in life due to chemotherapy- induced heart damage. The type of damage caused to the heart depends on the type of agent used during cancer treatment. It is expectable to observe ventricular impairment in patients treated with anthracyclines, while pyrimidines and some signalling inhibitors may damage the coronary circulation. Several techniques can be used to help diagnose early cardiac affections, such as biomarkers and auxiliary diagnostic tests. The information obtained can help physicians adjust chemotherapy doses, thus avoiding unnecessary heart damage. Although there is not yet a broad offer of cardioprotective drugs specific to these cases, some pharmacological agents used in common cardiology can also be applied here, such as beta-blockers and angiotensinogen- converting enzyme inhibitors.


Download data is not yet available.
Chemotherapy, cardiotoxicity, prevention, diagnosis, physiopathology.
Abstract views: 1045

PDF: 541
HTML: 32
Share it

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

How to Cite
Marmelo, F., & Sá, C. (2019). Physiopathology and diagnosis of cardiotoxicity in patients submitted to chemotherapy treatment. Oncology Reviews, 13(1).