Thrombocytopenia in solid tumors: Prognostic significance

  • Majid Ghanavat Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran, Islamic Republic of.
  • Mina Ebrahimi Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Islamic Republic of.
  • Hassan Rafieemehr Department of Medical Laboratory Sciences, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran, Islamic Republic of.
  • Mahmood Maniati Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Islamic Republic of.
  • Masumeh Maleki Behzad Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Islamic Republic of.
  • Saeid Shahrabi | sshahrabi45@yahoo.com Department of Biochemistry and Hematology, Faculty of Medicine, Semnan University Of Medical Sciences, Semnan, Iran, Islamic Republic of.

Abstract

Solid tumors are a heterogeneous group of malignancies that result from out-of-control proliferation of cells. Thrombocytopenia is a common complication among patients with solid tumors that predispose them to bleeding disorders. The aim of this review article is to investigate the underlying mechanisms of the risk and incidence of thrombocytopenia in solid tumors. It can be argued that thrombocytopenia is a poor prognostic factor in solid tumors that can result from several factors such as polymorphism and mutation in some transcription factors and cytokines involved in megakaryocytic maturation or from the adverse effects of treatment. Therefore, an understanding of the exact mechanism of thrombocytopenia pathogenesis in each stage of solid tumors can help in developing therapeutic strategies to decrease bleeding complications in these malignancies.

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Published
2019-05-14
Section
Reviews
Keywords:
Thrombocytopenia, solid tumors, chemotherapy, cytokines polymorphism.
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How to Cite
Ghanavat, M., Ebrahimi, M., Rafieemehr, H., Maniati, M., Maleki Behzad, M., & Shahrabi, S. (2019). Thrombocytopenia in solid tumors: Prognostic significance. Oncology Reviews, 13(1). https://doi.org/10.4081/oncol.2019.413

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