Recent trends in predictive biomarkers for determining malignant potential of oral potentially malignant disorders

  • Gargi S. Sarode Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India.
  • Sachin C. Sarode | drsachinsarode@gmail.com Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India. http://orcid.org/0000-0003-1856-0957
  • Nikunj Maniyar Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India.
  • Nilesh Sharma Cancer and Translational Research Lab, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India. http://orcid.org/0000-0002-8774-3020
  • Sujata Yerwadekar Department of Orthodontics and Dentofacial Orthopedics, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India.
  • Shankargouda Patil Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

Abstract

Despite of the tremendous advancements in the field of cancer prevention, detection and treatment, the overall prognosis of oral squamous cell carcinoma (OSCC) still remains poor. This can be partly imparted to the lack of early detection of oral potentially malignant disorders (OPMDs), especially those at a higher risk of progression into OSCC. Over years, various specific and non-specific markers have been introduced that could predict the malignant transformation of OPMDs; however detail information on these OPMD markers in a concise manner is lacking. Moreover, their use on daily clinical basis still remains questionable. With continuous research in the field of cytology and genomics, several contemporary biomarkers have been discovered that are not yet foregrounded and proved to be more promising than those used conventionally. Here, in the present paper, we overview several recently concluded predictive biomarkers with special emphasis on their role in molecular pathogenesis of OSCC transformation. These markers can be used for risk assessment of malignant transformation in patients with OPMDs as well as for prophylactic conciliation and fair management of the high-risk OPMD patient group.

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Published
2019-09-10
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Section
Reviews
Keywords:
Biomarkers, molecular pathogenesis, oral potentially malignant disorder, oral cancer, oral squamous cell carcinoma.
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How to Cite
Sarode, G. S., Sarode, S. C., Maniyar, N., Sharma, N., Yerwadekar, S., & Patil, S. (2019). Recent trends in predictive biomarkers for determining malignant potential of oral potentially malignant disorders. Oncology Reviews, 13(2). https://doi.org/10.4081/oncol.2019.424