The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma multiforme: a meta-analysis and systematic review

  • Ehsan Alimohammadi Neurosurgery Department, Kermanshah University of Medical Sciences, Kermanshah, Iran, Islamic Republic of.
  • Seyed Reza Bagheri Neurosurgery Department, Kermanshah University of Medical Sciences, Kermanshah, Iran, Islamic Republic of.
  • Shahram Taheri Neurosurgery Department, Kermanshah University of Medical Sciences, Kermanshah, Iran, Islamic Republic of.
  • Maliheh Dayani Radiooncology Department, Kermanshah University of Medical Sciences, Kermanshah, Iran, Islamic Republic of.
  • Alireza Abdi | A_abdi61@yahoo.com Nursing and Midwifery School, Kermanshah University of Medical Sciences, Kermanshah, Iran, Islamic Republic of.

Abstract

Surgical resection followed by concurrent radiation therapy and temozolomide (TMZ) chemotherapy is the current standard treatment for glioblastoma multiforme (GBM). The present metaanalysis investigated the impact of prolonged TMZ maintenance therapy (more than 6 cycles) in comparison with standard TMZ maintenance therapy (exactly six cycles) on overall survival (OS) and progression-free survival (PFS) of patients with GBM. A meta-analysis of the literature was conducted using Medline, PubMed, EMBASE and the Cochrane Library in accordance with PRISMA guidelines. Seven articles involving 1018 patients were included. The overall survival was higher in the case group (>6 cycles TMZ) compared to the control group (6 cycles TMZ) (Z=2.375, P=0.018). The lower and upper limits were between 1.002-10.467 months. The case group had higher progression-free survival compared with the control group (Z=3.84; P<0.001). The lower and upper limits were between 2.559-7.894 months. Evidence from this meta-analysis suggests that prolonged TMZ therapy compared to the standard 6-cycle TMZ therapy was associated with higher survival in patients with glioblastoma.

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Published
2020-02-18
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Issue
Section
Reviews
Keywords:
Glioblastoma multiforme, meta-analysis, overall survival, progression free survival, temozolomide.
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How to Cite
Alimohammadi, E., Bagheri, S. R., Taheri, S., Dayani, M., & Abdi, A. (2020). The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma multiforme: a meta-analysis and systematic review. Oncology Reviews, 14(1). https://doi.org/10.4081/oncol.2020.461