Alteration to the SWI/SNF complex in human cancers

https://doi.org/10.4081/oncol.2010.89
  • Vanessa S. Gordon | Vanessa.gordon@medicine.ufl.edu Division of Hematology/Oncology, University of Florida, Gainesville, United States.
  • Colin Rogers Division of Hematology/Oncology, University of Florida, Gainesville, United States.
  • David Reisman Division of Hematology/Oncology, University of Florida, Gainesville, United States.

Abstract

The SWI/SNF complex is a key catalyst for gene expression and regulates a variety of pathways, many of which have anticancer roles. Its central roles in cellular growth control, DNA repair, differentiation, cell adhesion and development are often targeted, and inactivated, during cancer development and progression. In this review, we will discuss what is known about how SWI/SNF is inactivated, and describe the potential impact of abrogating this complex. BRG1 and BRM are the catalytic subunits which are essential for SWI/SNF function, and thus, it is not surprising that they are lost in a variety of cancer types. As neither gene is mutated when lost, the mechanism of suppression, as well as the impact of potential gene activity restoration, are reviewed.

Downloads

Download data is not yet available.
Published
2011-12-05
Issue
Vol 4, No 2 (2010)
Section
Reviews
Keywords:
Brahma related gene 1 (BRG1) - Brahma (BRM) - SWI/SNF complex - Tumor suppressor - Epigenetic - Retinoblastoma protein - Subunits - Cancer progression
Statistics
Abstract views: 1022

FULL TEXT: 179
Share it

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

How to Cite
Gordon, V. S., Rogers, C., & Reisman, D. (2011). Alteration to the SWI/SNF complex in human cancers. Oncology Reviews, 4(2), 89-99. https://doi.org/10.4081/oncol.2010.89

Copyright (c) 2011 Vanessa S. Gordon, Colin Rogers, David Reisman

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.