Molecular pharmacokinetic determinants of anticancer kinase inhibitors in humans

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Julie Scholler *
Dominique Leveque
(*) Corresponding Author:
Julie Scholler | dominique.leveque@chru-strasbourg.fr

Abstract

This review presents the published data regarding the molecular determinants (drug metabolizing enzymes, drug transporters and orphan nuclear receptors) of approved anticancer kinase inhibitors pharmacokinetics in humans. The clinical impact of these determinants (drug disposition and drug–drug interactions) is also discussed.

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