A role of active brown adipose tissue in cancer cachexia?

Main Article Content

Emiel Beijer
Janna Schoenmakers
Guy Vijgen
Fons Kessels
Anne-Marie Dingemans
Patrick Schrauwen
Miel Wouters
Wouter van Marken Lichtenbelt
Jaap Teule
Boudewijn Brans *
(*) Corresponding Author:
Boudewijn Brans | b.brans@mumc.nl

Abstract

Until a few years ago, adult humans were not thought to have brown adipose tissue (BAT). Now, this is a rapidly evolving field of research with perspectives in metabolic syndromes such as obesity and new therapies targeting its bio-energetic pathways. White, brown and socalled brite adipose fat seem to be able to trans-differentiate into each other, emphasizing the dynamic nature of fat tissue for metabolism. Human and animal data in cancer cachexia to date provide some evidence for BAT activation, but its quantitative impact on energy expenditure and weight loss is controversial. Prospective clinical studies can address the potential role of BAT in cancer cachexia using 18F-fluorodeoxyglucose positron emission tomography-computed tomography scanning, with careful consideration of co-factors such as diet, exposure to the cold, physical activity and body mass index, that all seem to act on BAT recruitment and activity.

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Author Biographies

Emiel Beijer, Department of Nuclear Medicine, University Medical Center, Maastricht

M.Sc.

Guy Vijgen, Departments of Surgery; Human Biology; NUTRIM School for Nutrition, Toxicology and Metabolism, University Medical Center, Maastricht

M.D.

Fons Kessels, Department of Clinical Epidemiology and Medical Technology Assessment (MTA); CAPHRI School for Public Health and Primary Careh, University Medical Center, Maastricht

Ph.D.

Anne-Marie Dingemans, Department of Respiratory Medicine; GROW School for Oncology and Developmental Biology, University Medical Center, Maastricht

M.D., Ph.D.

Patrick Schrauwen, Department of Human Biology; NUTRIM School for Nutrition, Toxicology and Metabolism, University Medical Center, Maastricht

Ph.D.

Miel Wouters, Department of Respiratory Medicine; NUTRIM School for Nutrition, Toxicology and Metabolism, University Medical Center, Maastricht

M.D., Ph.D.

Wouter van Marken Lichtenbelt, Department of Human Biology; NUTRIM School for Nutrition, Toxicology and Metabolism, University Medical Center, Maastricht

Ph.D.

Jaap Teule, Department of Nuclear Medicine, University Medical Center, Maastricht

M.D., Ph.D.

Boudewijn Brans, Department of Nuclear Medicine; GROW School for Oncology and Developmental Biology, University Medical Center, Maastricht

M.D., Ph.D.