Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases

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Luigi Rossi
Angelo Zullo
Federica Zoratto
Anselmo Papa
Martina Strudel
Maria Colonna
Silverio Tomao *
(*) Corresponding Author:
Silverio Tomao |


Although surgery is the most effective treatment for liver metastases in colorectal cancer patients, only 15-20% of these patients are suitable for a radical surgical approach, and metastases recurrence may occur at follow up. In the last decade, the use of pre-operative chemotherapy in combination with new biological drugs has been introduced. We reviewed data of neo-adjuvant chemotherapy strategies aimed at increasing the resection rate of liver metastases in colorectal cancer patients who were initially considered unresectable.

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