Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases

  • Luigi Rossi Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina – “Sapienza” University of Rome, Italy.
  • Angelo Zullo Gastroenterology and Digestive Endoscopy; Nuovo Regina Margherita Hospital, Rome, Italy.
  • Federica Zoratto Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina – “Sapienza” University of Rome, Italy.
  • Anselmo Papa Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina – “Sapienza” University of Rome, Italy.
  • Martina Strudel Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina – “Sapienza” University of Rome, Italy.
  • Maria Colonna
  • Silverio Tomao | silverio.tomao@uniroma1.it Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina – “Sapienza” University of Rome, Italy.

Abstract

Although surgery is the most effective treatment for liver metastases in colorectal cancer patients, only 15-20% of these patients are suitable for a radical surgical approach, and metastases recurrence may occur at follow up. In the last decade, the use of pre-operative chemotherapy in combination with new biological drugs has been introduced. We reviewed data of neo-adjuvant chemotherapy strategies aimed at increasing the resection rate of liver metastases in colorectal cancer patients who were initially considered unresectable.

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Published
2012-06-14
Section
Reviews
Keywords:
liver metastasis, colorectal cancer, chemotherapy, neo-adjuvant chemotherapy, biological therapy, bevacizumab, cetuximab.
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How to Cite
Rossi, L., Zullo, A., Zoratto, F., Papa, A., Strudel, M., Colonna, M., & Tomao, S. (2012). Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases. Oncology Reviews, 6(1), e6. https://doi.org/10.4081/oncol.2012.e6